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Clarithromycin or azithromycin have been associated with clinical response in certain cases and are considered second line alternatives (bii), although treatment failures have been reported with both drugs.	Objectie sought to determine whether clarithromycin, a newer macrolide antibiotic, can alter the pharmacokinetic profile of oral glucocorticoids and thereby increase the risk of steroid-induced adverse effects. Gp has prescribed clarithromycin and said that poos may get a bit runny but will not really affect him.	Clarithromycin shows promise as an effective agent for the treatment of early lyme disease and warrants further study.

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