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| Furthermore, we believe that pre-treatment with drugs used in these combinations, in particular the macrolide antibiotics clarithromycin and azithromycin, may increase the likelihood of ending up with antibiotic resistant mycobacterium avium subspecies paratuberculosis in the patient. We defined a resistant case to be an harp isolate that demonstrated any detectable resistance to metronidazole, clarithromycin, tetracycline, or amoxicillin. | There are also data that clarithromycin has a similar effect, and likely that azithromycin does as well. |
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